Skinscienceantimicrobialspray Antimicrobial peptides (AMPs) are a crucial component of the skin's innate immune system, acting as a vital defense mechanism against invading microorganisms. These naturally occurring molecules are produced by both resident skin cells and infiltrating immune cells, forming a critical barrier that protects against a wide range of pathogens. While some AMPs are constantly present in healthy skin, their production can increase significantly in response to microbial invasion, highlighting their dynamic role in maintaining skin health and integrity. Understanding the function and potential of antimicrobial peptides in the skin is essential for comprehending skin immunity and exploring novel therapeutic avenues for various skin conditions.
The skin serves as the body's primary interface with the external environment, constantly facing challenges from bacteria, fungi, and viruses. Antimicrobial peptides are at the forefront of this defense, exhibiting broad-spectrum antimicrobial activity. They work by directly killing target microbes through diverse mechanisms, often by disrupting their cell membranes. Major classes of these peptides found in the epidermis include cathelicidins and defensinsPeptide Antimicrobial Agents - PMC - NIH. Beyond their direct antimicrobial effects, AMPs also play immunomodulatory roles, influencing inflammation and contributing to the resolution of infections and wound healing.作者：V Nizet·2001·被引用次数：1571—Here we show that cathelicidins are an important native component of innate host defence in mice andprovide protection against necrotic skin infection. This dual action makes them indispensable for maintaining a healthy skin microbiome and preventing invasive infections.
The presence and activity of AMPs are closely linked to the overall health of the skin. In normal, healthy skin, a certain level of specific AMPs ensures continuous protectionPeptide Antimicrobial Agents - PMC - NIH. However, disruptions in AMP production or function can contribute to various skin diseases.作者：SB Adnan·2025·被引用次数：21—This review aims to provide a comprehensive synthesis of the current evidence on the dual role of AMPs as bothantimicrobialand immunomodulatory agents in the ... For instance, imbalances in the skin's AMP profile have been implicated in conditions like atopic dermatitis, where impaired skin barrier function and altered microbial communities are observed. Conversely, AMPs show promise as therapeutic options for conditions such as skin and soft tissue infections (SSTIs) and skin wound healing.Skin microbiome and antimicrobial peptides Their ability to combat pathogens with low resistance development potential makes them attractive candidates for developing new treatments.作者：NI Md Fadilah·2024·被引用次数：25—This current review explores the fascinating realm ofbioactive peptides as promising therapeutic agents for skin wound healing.
The therapeutic potential of antimicrobial peptides for skin applications is a rapidly growing area of research. Their ability to penetrate deeper skin layers and their broad antimicrobial spectrum, which extends to Gram-negative and Gram-positive bacteria, enveloped viruses, and fungi, make them valuable. Furthermore, research is exploring their capacity to address issues like acne by targeting bacteria responsible for breakouts.Antimicrobial peptideshave been demonstrated to kill Gram negative and Gram positive bacteria, enveloped viruses, fungi and even transformed or cancerous cells ... The development of effective delivery systems for AMPs is crucial for their successful application in treating skin infections and promoting wound healing. As our understanding of the skin microbiome and the intricate roles of AMPs deepens, these peptides are poised to become increasingly important in both maintaining skin health and treating a range of dermatological conditions.
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