AntiLysyl oxidase injection The search for "anti-lox peptide" primarily concerns peptides that inhibit or are directed against lysyl oxidase (LOX)A synthetic peptide corresponding to a sequence in the middle region of human LOX, different from the related mouse and rat sequences by one amino acid. Cross- .... Lysyl oxidase is an essential extracellular enzyme involved in crucial biological processes such as collagen and elastin cross-linking, extracellular matrix formation and repair, cell motility, and even developmental regulation. Understanding anti-LOX peptides involves exploring their role in scientific research, particularly in antibody development and as potential therapeutic agents作者：M Cetin·2024·被引用次数：21—A highly potent bi-thiazole inhibitor ofLOXrewires collagen architecture and enhances chemoresponse in triple-negative breast cancer..
Lysyl oxidase (LOX) is a copper-dependent amine oxidase that catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagens and elastin. This enzymatic activity is fundamental for the structural integrity and mechanical properties of connective tissues. LOX family members also play roles in cell signaling and can be dysregulated in various pathological conditions, including fibrosis and cancer, making them targets for intervention. The gene encoding LOX may also be referred to as Xlox or AAT10.Target.LOX (Lysyl Oxidase (LOX)) ; Origin. Human ; Source. Synthetic ; Application. Blocking Peptide (BP), Immunogen (Imm) ; Protein Region. Internal Region ...
Anti-LOX peptides are frequently utilized in scientific contexts, primarily as:
* Blocking Peptides: These synthetic peptides correspond to specific sequences of the LOX protein. They are used in immunological assays, such as Western blotting or ELISA, to confirm the specificity of anti-LOX antibodies. By pre-incubating an antibody with its corresponding blocking peptide, researchers can verify that the antibody is indeed binding to the intended LOX antigen and not to other proteins. This is crucial for accurate experimental results.
* Immunogens: Peptides can also serve as immunogens, meaning they are used to generate antibodies against the LOX protein. By injecting a synthetic peptide representing a region of LOX into an animal (like a rabbit or goat), antibodies specific to that peptide, and thus to LOX, can be produced.
* Research Tools: Beyond antibody validation, certain anti-LOX peptides are investigated for their intrinsic biological activities. Some studies have identified peptides with anti-LOX activity, suggesting their potential to modulate LOX function.Anti-Lysyl Oxidase (LOX) Antibody | ABT112 These can range from short peptides (three to nine residues) to longer sequences derived from protein hydrolysates.Anti-lysyl oxidase supplement
The term "anti-LOX" in the context of peptides often refers to components used in the production or application of anti-Lysyl Oxidase antibodies. These antibodies are essential tools for researchers studying LOX作者：L Leung·2019·被引用次数：82—We report herein the medicinal chemistry discovery of a series ofLOXinhibitors bearing an aminomethylenethiophene (AMT) scaffold.. They are available from various sources and can be raised in different hosts, such as rabbits or goats, often using synthetic peptides as the immunizing agentlysyl Oxidase (LOX) Antibody. These antibodies are valuable for detecting, quantifying, and localizing LOX in biological samples through techniques like Western blotting (WB), immunohistochemistry (IHC), and immunoprecipitation (IP). Some anti-LOX antibodies are specifically designed to detect particular forms of LOX, such as the pro-enzyme or pro-peptide.
While much of the current use of anti-LOX peptides is within research laboratories, there is growing interest in their therapeutic implications.LOX Antibody (F-8): sc-373995 Lysyl oxidase, particularly certain members of the LOX family like LOXL2, has been implicated in diseases such as osteoarthritis (OA) due to its role in cartilage degradation. Inhibitors of LOX, which could include specific peptide-based molecules or related compounds, are being explored as potential treatmentsB66. THE FIBROBLAST POOL ON THE MOVE. Research into these inhibitors aims to block the pro-anabolic and chondroprotective roles that LOXL2 might play, suggesting a complex role in disease that warrants further investigation.作者：T Takihara·2012—APeptideDerived From Endostatin ExhibitsAnti-fibrotic Activity By Reducing The Expression Of Lysyl Oxidase (LOX) And Early Growth Response-1 (Egr-1). Moreover, some studies explore the combination of anti-LOX strategies with other devices or agents for potential physiological effects, such as promoting tissue lengthening.LOX Antibody Blocking Peptide (NB100-2530PEP)
When working with anti-LOX peptides, particularly those used for antibody blocking, it is essential to ensure the peptide sequence is relevant to the specific LOX protein or isoform being studied.Goat polyclonal antibody to LOXfor ELISA and WB. Proteins predicted to interact with LOX. Predicted protein interactions based upon String database. The origin of the peptide (e.g., human, mouse, rat) and the region of the LOX protein it represents can significantly impact its effectiveness.Goat polyclonal antibody to LOXfor ELISA and WB. Proteins predicted to interact with LOX. Predicted protein interactions based upon String database. Similarly, when considering peptides with reported anti-LOX activity, understanding their specific mechanism of action and potency (e.g., IC50 values) is crucial for evaluating their research or therapeutic potential.Anti-LOX Human Protein Atlas Antibody
Join the newsletter to receive news, updates, new products and freebies in your inbox.