AntiLOX
The anti-lysyl oxidase peptide is a critical tool in scientific research, primarily used to study and inhibit the activity of lysyl oxidase (LOX) enzymesAnti-Lysyl Oxidase (LOX) Antibodyis an antibody against Lysyl Oxidase (LOX) for use in Western Blotting, IHC(P).. These enzymes play a vital role in the extracellular matrix, particularly in collagen and elastin cross-linking, which is essential for tissue structure and integrity.The DNA sequence encodes a polypeptide of 417 amino acids, the first 21 residues of which constitute a signalpeptide, with a weight of approximately 32 kDa. Consequently, anti-LOX peptides and antibodies are valuable for investigating a range of biological processes and pathological conditions, including fibrosis, cancer, and tissue remodeling.
Lysyl oxidases are a family of copper-dependent amine oxidases that catalyze the oxidative deamination of specific lysine and hydroxylysine residues in collagen and elastin. This process is foundational for the formation of stable intermolecular cross-links, which confer mechanical strength and resilience to connective tissues作者：Y Zhao·2009·被引用次数：76—Thelysyl oxidase(LOX)2 gene family is comprised of five members LOX, LOXL1, LOXL2, LOXL3, and LOXL4, which encode enzymes that modify extracellular matrix ( .... The LOX enzyme family includes LOX and several LOX-like proteins (LOXL1-LOXL4), each with distinct but related functions in tissue development, maintenance, and disease. Research into these enzymes has revealed their involvement in processes as diverse as wound healing, arterial calcification, tumor suppression, and the progression of fibrotic diseases.Anti-Lysyl Oxidase (LOX)
Anti-lysyl oxidase peptides are often synthesized to mimic specific regions of the LOX protein, typically used as immunogens to generate antibodies or as blocking peptides to neutralize antibody binding.Anti-Lysyl Oxidase (LOX) Antibodyfrom rabbit, purified by affinity chromatography; Synonyms: Protein-lysine 6-oxidase, Lysyl oxidase at Sigma-Aldrich. This allows researchers to precisely target and study LOX activityGoat anti-lysyl oxidase Antibody; Principle Name, lysyl oxidase ; Official Symbol, LOX ; All Name and Symbols, LOX; lysyl oxidase; protein-lysine 6-oxidase.. For instance, a LOX peptide can be used in conjunction with an anti-LOX antibody to confirm the specificity of antibody-based detection methods, such as Western blotting or immunohistochemistryAnti-Lysyl oxidase Antibody Products. By pre-incubating the antibody with its corresponding peptide, researchers can demonstrate that the antibody indeed binds to the intended target, thereby validating experimental results.
Furthermore, synthetic peptides derived from LOX can also serve as inhibitors or modulators of LOX enzyme activity. Studies have explored the use of anti-LOX antibodies and related peptides in therapeutic contexts. For example, research has investigated how anti-lysyl oxidase treatments, sometimes in combination with other devices, might influence tissue remodeling, such as in studies exploring penile lengtheningAnti-Lysyl Oxidase (LOX). While this specific application is niche, it highlights the broader potential of targeting LOX activity to alter tissue properties.
The primary utility of anti-LOX peptides and antibodies lies in their application in various research fields:
* Fibrosis Research: LOX enzymes are implicated in the excessive deposition of extracellular matrix proteins characteristic of fibrotic diseases affecting organs like the lungs, liver, and kidneysAnti-Lysyl oxidase Antibody Products. Anti-LOX agents are used to investigate the role of LOX in driving fibrosis and to explore potential therapeutic strategies to inhibit this process. For example, peptide-derived from endostatin has shown anti-fibrotic activity by reducing LOX expression.
* Cancer Biology: LOX and its family members have been linked to tumor progression, metastasis, and angiogenesis.Anti-Lysyl Oxidaseantibody produced in rabbit (Anti-LOX ); ~ 1mg/mL, affinity isolated antibody, buffered aqueous solution; Suitable for western blot; ... They can influence the tumor microenvironment, promote cell migration, and contribute to resistance to chemotherapyanti-LOX antibody :: Goat lysyl oxidase Polyclonal .... Researchers use anti-LOX antibodies and peptides to study these mechanisms and to evaluate LOX inhibitors as potential anti-cancer agents. Some studies investigate how inhibitors can "rewire" collagen architecture, enhancing chemotherapy response in triple-negative breast cancer.Anti-Lysyl Oxidase (L4794) - Data Sheet - Sigma-Aldrich
* Tissue Engineering and Regenerative Medicine: The role of LOX in cross-linking extracellular matrix components makes it relevant to tissue engineering efforts aimed at creating functional biomaterials and tissues. Understanding how to modulate LOX activity could be crucial for controlling the mechanical properties and degradation rates of engineered tissues.
* Vascular Health: LOX is involved in the structural integrity of blood vesselsLysyl Oxidase Homolog 2/LOXL2 Antibody (262418). Lysyl oxidase deficiency has been identified as a cause of human arterial dissection, underscoring the enzyme's critical importance in vascular health. Research using anti-LOX tools helps elucidate these roles and potential therapeutic targets for vascular diseasesAnti-lysyl oxidase combined with a vacuum device induces ....
When working with anti-lysyl oxidase peptides, it is essential to consider their source, purity, and intended application.Target.LOX (Lysyl Oxidase (LOX)) ; Origin. Human ; Source. Synthetic ; Application. Blocking Peptide (BP), Immunogen (Imm) ; Protein Region. Internal Region ... Synthetic peptides are often preferred for their defined sequences and high purity.AB041. Anti-Lysyl oxidase combined with vacuum aspiration ... Researchers must also be aware of the different members of the LOX family, as antibodies and peptides may exhibit varying degrees of specificity towards LOX versus LOXL proteins.Lysyl oxidase: properties, regulation and multiple functions in biology
The development of novel LOX inhibitors, including peptide-based ones, continues to be an active area of research. These agents hold promise for treating a spectrum of diseases characterized by aberrant extracellular matrix remodeling.Anti-lysyl oxidase combined with a vacuum device induces ... As our understanding of the intricate roles of lysyl oxidases in health and disease deepens, the importance of tools like anti-lysyl oxidase peptide will undoubtedly grow, paving the way for new diagnostic and therapeutic interventions.
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