Anaspecmog The MOG peptide 35-55 is a critical research tool used to model neurological diseases, particularly those involving demyelination.Immunizing mice withMOG(35-55)peptideto induce experimental autoimmune encephalomyelitis (EAE), it causes inflammation (macrophages and CD3+ T lymphocytes), ... This specific peptide fragment derived from Myelin Oligodendrocyte Glycoprotein (MOG) is instrumental in inducing experimental autoimmune encephalomyelitis (EAE), a condition that closely mimics the pathology and symptoms of multiple sclerosis (MS) in animal models. Researchers utilize MOG peptide 35-55 to study the mechanisms of autoimmune responses against myelin, investigate potential therapeutic interventions, and understand the development of relapsing-remitting neurological disease with extensive plaque-like demyelination.
The Myelin Oligodendrocyte Glycoprotein (MOG) is a protein found in the central nervous system's myelin sheath, which insulates nerve fibersMOG(35-55) enables researchers to explore the processes involved in autoimmune diseases such as multiple sclerosis. Its use in research allows scientists to .... Antibodies or T cell responses directed against MOG are implicated in certain autoimmune demyelinating disorders.MOG peptide(35-55) amide, a myelin oligodendrocyte glycoprotein (MOG) fragment spanning amino acids 35 to 55, selectively stimulates CD4+ T cell expansion and ... The MOG peptide 35-55 sequence is recognized as a key immunodominant epitope, meaning it is a primary target for the immune system when attempting to induce an autoimmune response.MOG peptide(35-55) amide, a myelin oligodendrocyte glycoprotein (MOG) fragment spanning amino acids 35 to 55, selectively stimulates CD4+ T cell expansion and ... By administering this peptide, often emulsified in an adjuvant, researchers can reliably trigger an immune attack on the myelin sheath, leading to the development of EAE.Myelin oligodendrocyte glycoprotein (MOG) (35-55) is an antigenpeptideofMOG, a protein involved in demyelinating CNS disorders. ...MOG(35-55) in combination ... This experimental model is invaluable for studying the pathogenesis of diseases like multiple sclerosis and MOG antibody disease.
The induction of Experimental Autoimmune Encephalomyelitis (EAE) is the most common application for MOG peptide 35-55. When injected into susceptible animal strains, such as C57BL/6 mice, this peptide acts as an antigen. The immune system recognizes it as foreign and mounts a response, generating autoantibodies and activating T cells. These activated immune cells then migrate to the central nervous system, where they attack the myelin sheath, causing inflammation and demyelinationMOG (35-55) (2568) by Tocris, Part of Bio-Techne. The resulting EAE model exhibits a range of symptoms, including paralysis and neurological deficits, which can be monophasic or relapsing-remitting, mirroring aspects of human neurological conditions.MOG (35-55) human – MEVGWYRPPFSRVVHLYRNGK The specific sequence, often represented by MEVGWYRPPFSRVVHLYRNGK, is crucial for its encephalitogenic properties.
The use of MOG peptide 35-55 extends beyond simply inducing EAE. It serves as a vital tool for:
* Investigating Autoimmune Mechanisms: Researchers use this peptide to dissect the specific immune cells and molecular pathways involved in myelin damage. This includes studying the roles of different T cell subsets (like Th1, Th17, and regulatory T cells) and antibody production.
* Developing and Testing Therapies: By creating an animal model that recapitulates aspects of MS and other demyelinating diseases, scientists can evaluate the efficacy of novel therapeutic agents. This can include testing immunosuppressants, anti-inflammatory drugs, or strategies aimed at promoting myelin repair.
* Understanding Disease Heterogeneity: Variations in the EAE model induced by MOG peptide 35-55 can help researchers understand why demyelinating diseases manifest differently in individuals.The fragment35-55fromMOGprotein is able to induce a model of demyelinating of the myelin sheath : EAE (Experimental autoimmune encephalomyelitis). Induction ... Factors like genetic background of the animal model and the specific formulation of the peptide can influence disease severity and progression.
* Studying MOG Antibody Disease (MOGAD): While EAE is primarily a T cell-mediated disease, MOG is also a target for antibodies in conditions like MOGADBuy Myelin Oligodendrocyte Glycoprotein(35-55), ratMOG(35-55) measures levels or activity, provides reproducible results in experiments for studying .. The MOG peptide 35-55 can be used in assays to detect and characterize anti-MOG antibodies.Application ofMOGProtein (35-55) induces an autoantibody response that serves as a model of experimental autoimmune encephalomyelitis and multiple sclerosis.
Researchers often seek high-purity MOG peptide 35-55 to ensure reliable and reproducible experimental results. These peptides are typically synthesized and supplied by specialized biochemical companies.MOG Antibody Disease - Symptoms, Causes, Treatment | NORD Key considerations when selecting a supplier include the peptide's purity (often assessed by HPLC), its formulation (e.g., TFA salt or amide form), and whether it is intended for specific species (human, mouse, rat). The consistency and quality of the peptide are paramount for accurate disease modeling and therapeutic testingImmunizing mice withMOG(35-55)peptideto induce experimental autoimmune encephalomyelitis (EAE), it causes inflammation (macrophages and CD3+ T lymphocytes), ....
In conclusion, the MOG peptide 35-55 is an indispensable reagent in neuroscience and immunology research, providing a robust platform for studying the complex mechanisms underlying demyelinating diseases and for advancing the development of potential treatmentsMOG(35-55) : Encephalitogenic myelin oligodendrocyte glycoprotein fragment. ≥95% (HPLC).. Its ability to reliably induce experimental autoimmune encephalomyelitis makes it a cornerstone for understanding and combating conditions like multiple sclerosis.
Join the newsletter to receive news, updates, new products and freebies in your inbox.