Mog3555sequence The MOG 35-55 peptide is a crucial tool in neuroscience research, particularly for understanding and modeling autoimmune demyelinating diseases like multiple sclerosis (MS)Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35 .... This specific peptide fragment, derived from the Myelin Oligodendrocyte Glycoprotein (MOG), is widely used to induce experimental autoimmune encephalomyelitis (EAE) in animal models.Myelin oligodendrocyte glycoprotein (MOG)peptide 35-55is one of the targets of self-reactive T cell responses, leading to acute and later chronic autoimmune ... EAE closely mimics the pathological hallmarks of MS, including inflammation and demyelination in the central nervous system, making MOG (35-55) an invaluable reagent for studying disease mechanisms and testing potential therapeutic interventions.
Myelin oligodendrocyte glycoprotein (MOG) is a protein found on the surface of myelin sheaths in the central nervous systemMOG (35-55) TFA (Myelin Oligodendrocyte Glycoprotein .... In certain autoimmune conditions, the immune system mistakenly targets MOG, leading to the destruction of myelinMOG (35-55), human - 1 mg. The MOG 35-55 peptide fragment specifically represents an immunodominant epitope within the MOG protein.Multiple SclerosisPeptide–.MOG(35-55) rat/mouse. Product. Cat#. Package size.MOG(35-55) rat/mouse TFA salt (>95% - HPLC 214nm). P2265.9505. 5mg. Sequence. When administered to susceptible animal models, such as mice and rats, this peptide elicits a robust immune response characterized by T cell activation and the production of autoantibodies against MOG. This immune assault results in significant demyelination and neurological dysfunction, closely mirroring the relapsing-remitting and chronic progressive forms of multiple sclerosis observed in humans... (35-55)-induced experimental autoimmune encephalomyelitis (EAE) C57/BL6 mice and Lewis rats. Every lot ofMOG(35-55)peptideis tested and proven to induce EAE.. Researchers utilize this induced EAE model to investigate the intricate interplay between the immune system and the central nervous system, seeking to identify key cellular and molecular pathways that drive disease pathogenesis.
The primary utility of the MOG 35-55 peptide lies in its ability to reliably induce a predictable EAE modelMOG(35-55)peptide, mouse - 2x5 mg - SB023-2*5MG from sb-Peptide.. This allows scientists to:
* Investigate Autoimmune Mechanisms: By studying the immune response triggered by MOG (35-55), researchers gain insights into the specific T cell epitopes that are recognized as foreign, the signaling pathways involved in inflammation, and the mechanisms by which myelin is damaged.
* Evaluate Therapeutic Efficacy: Pre-clinical studies often employ the MOG (35-55) induced EAE model to test the effectiveness of novel drugs and therapies designed to treat MSMOG(35-55), Human_UA080263_斯达特公司官网. This includes evaluating agents that might suppress the immune response, protect myelin, or promote remyelination.
* Study Disease Progression and Pathology: The peptide allows for the controlled induction of demyelinating lesions, enabling detailed examination of the pathological changes that occur during the disease course, from acute inflammation to chronic neurodegeneration.97% (HPLC) CAS Number: 163913-87-9; Synonyms:MOG Peptide 35-55Rat, Mouse at Sigma-Aldrich.
* Explore Genetic and Environmental Factors: Researchers can use the MOG (35-55) model to investigate how genetic predispositions or environmental factors might influence disease susceptibility and severity.
High-purity MOG 35-55 peptide is essential for reproducible research outcomesMOG (35-55), human - 1 mg. Suppliers typically offer the peptide in various forms, often as a TFA (trifluoroacetate) salt, and specify purity levels, usually determined by HPLC (High-Performance Liquid Chromatography)Myelin oligodendrocyte glycoprotein (MOG)peptide 35-55is one of the targets of self-reactive T cell responses, leading to acute and later chronic autoimmune .... The sequence of the MOG 35-55 peptide, often represented as MEVGWYRPPFSRVVHLYRNGK, is critical for its immunogenic properties.MOG(35-55) : Encephalitogenic myelin oligodendrocyte glycoprotein fragment. ≥95% (HPLC). Researchers must ensure that the peptide is sourced from reputable vendors to guarantee its quality, integrity, and ability to consistently induce EAE.Behavioral and pathological outcomes in MOG 35–55 ... Storage conditions, typically at -20°C, are also important for maintaining peptide stability.Species. Human · 分子别名. Myelin Oligodendrocyte GlycoproteinPeptideFragment35-55Human · 表达序列. MEVGWYRPPFSRVVHLYRNGK · 分子量. 2592.02 · 纯度. ≥95% · 性状.
While MOG is a significant target in autoimmune CNS diseases, the 35-55 fragment is particularly notable for its encephalitogenic propertiesMyelin Oligodendrocyte Glycoprotein Peptide (35-55), Rat, .... Other fragments of MOG may also be immunogenic or play roles in immune responses, but the 35-55 sequence is the most widely recognized and utilized for inducing EAE models that closely replicate the pathology of multiple sclerosis. This specificity makes it a valuable and distinct tool in the field of neuroimmunology.
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