Peptides Peptide M is a synthetic peptide, specifically an 18-amino acid sequence derived from streptococcal M protein. Its primary known function is its ability to bind to both monomeric and dimeric forms of human immunoglobulin A (IgA), including both IgA1 and IgA2 subclasses, with high specificity and affinity. This property makes Peptide M a valuable tool in immunological research, particularly for the purification of IgA antibodies.Peptide M | CAS#:110652-62-5 | Chemsrc
The exact amino acid sequence for Peptide M is DTNLASSTIIKEGIDKTV. This sequence corresponds to amino acids 303-322 of the bovine S protein, and it contains an additional C-terminal cysteine residue. The synthetic nature of Peptide M allows for precise control over its structure and purity, which is crucial for its applications in research and diagnostics. While derived from streptococcal M protein, it is important to note that Peptide M itself is a synthesized entity, not the naturally occurring protein.
One of the most significant applications of Peptide M is in affinity purification of IgA antibodies. The peptide's high affinity for IgA allows it to be immobilized onto a solid support, such as agarose beads, creating a specialized chromatography matrixM Peptide. Researchers can then pass samples containing IgA through this Peptide M-conjugated matrix. The IgA antibodies will bind to the Peptide M, while other proteins and molecules in the sample will pass through.Peptide Mis a 50 aa synthetic peptide derived from a streptococcal M protein containing an additional C-terminal cysteine residue. Skip to the end of the ... The bound IgA can then be eluted under specific conditions, yielding a highly purified IgA preparation. This method is particularly useful for isolating mouse IgA, as indicated by related searches for "mouse IgA purification.Peptide M peptide"
Peptide M has a chemical formula of C81H141N21O31 and a molecular weight of approximately 1905.11. It is typically supplied as a lyophilized powder. For optimal long-term storage, it should be kept at or below -20°C in a sealed container.植物小肽研究进展Ⅰ：来源、鉴定和调控 - 土壤 When reconstituted in a solvent (mother liquor), its stability is generally around 6 months at -20°C and up to 1 year at -80°C. The peptide's composition includes a relatively high proportion of hydrophobic amino acids, which can affect its solubility; it is often described as not being highly water-soluble链球菌M蛋白多肽/110652-62-5/Peptide M 品牌.
While its primary use is in IgA purification, research into peptides and their interactions continues to expand.Peptide M | C81H141N21O31 | CID 16208244 - PubChem - NIH Related searches for "peptides" and "M peptides" suggest a broader interest in peptide science. For instance, studies explore interfering peptides like M1-20 that can inhibit protein interactions, or the design of "peptide masks" for controlling binder activity. The field of peptide sequencing and mass spectrometry, as indicated by terms like "PeptideMass" and "THE ABC'S (AND XYZ'S) OF PEPTIDE SEQUENCING," underpins the development and characterization of such synthetic peptides. The potential for peptides to act as therapeutic agents or diagnostic tools is an ongoing area of investigation.
In summary, Peptide M is a well-defined synthetic peptide with a crucial role in immunological research, primarily for the purification of IgA antibodies. Its specific binding properties and chemical characteristics make it an indispensable tool for researchers working with immunoglobulin A.
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