OVA peptidesequence The dominant search intent for "ova 257 264 peptide" is to understand this specific peptide's nature, its origin, and its role in immunological research. The SERP results consistently highlight that it's a Class I (Kb)-restricted peptide epitope derived from ovalbumin (OVA), often presented by the H-2Kb MHC molecule. It's frequently referred to by its sequence, SIINFEKLOvalbumin-derived peptideknown to arise from a natural processing of ovalbumin H-2b mouse cells. Subcutaneous immunization with this peptide could induce OVA- ....
Tier 1:
* Core Entity: OVA Peptide (257-264)
* Key Attributes/Descriptions: Class I (Kb)-restricted, peptide epitope, derived from ovalbumin (OVA), presented by H-2Kb MHC molecule, octameric peptide, SIINFEKL sequence.
* Primary Use Case: Stimulating T cells, detecting CD8+ cytolytic T-cell response.
Tier 2:
* Related Entities: Ovalbumin (OVA), MHC Class I, H-2Kb, SIINFEKL.
* Related Concepts: Immunological research, T-cell activation, CD8+ T-cell response, ELISPOT assay, flow cytometric analysis, immunohistochemical staining.
* Variations: OVA Peptide (257-264) TFA, OVA 257-264 scrambledOVA Peptide (257-264).
* Source: Chicken ovalbumin抗原肽；OVA（257-264） - 楚肽生物科技.
Tier 3:
* General terms like "peptide," "ovalbumin - an overview," "PubChem," chemical formulas, specific company product codes, and repeated mentions of basic definitions that don't add significant new information.
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The OVA peptide (257-264), often identified by its amino acid sequence SIINFEKL, is a critical and well-characterized peptide epitope derived from ovalbumin (OVA). This specific octameric peptide is recognized for its role as a Class I (Kb)-restricted peptide epitope, meaning it is presented by the MHC Class I molecule, specifically the H-2Kb variant, to T cells.OVA Peptide (257-264),1mg Its precise structure and presentation pathway make it an invaluable tool in immunological research, particularly for studying T-cell responsesOVA Peptide(257-264).
Ovalbumin, the primary protein found in egg whites, serves as the source for this immunodominant epitope. The peptide fragment spanning amino acids 257 to 264 has garnered significant attention because it is efficiently processed and presented by MHC Class I molecules on the surface of antigen-presenting cells.OVA 257-264 (SIINFEKL) is a well-characterized, immunodominant epitope derived from chicken ovalbumin protein (Uniprot P01012). This presentation is crucial for the activation of CD8+ cytotoxic T lymphocytes (CTLs), which play a vital role in cell-mediated immunity, recognizing and eliminating infected or cancerous cellsOVA 257 264 peptide (SIINFEKL)– CAS: 138831-86-4. The H-2Kb molecule, prevalent in certain mouse strains, is particularly adept at binding and displaying the SIINFEKL peptide, making it a standard model for investigating CTL responsesOVA [257-264] Peptide.
The OVA peptide (257-264) is widely utilized in various immunological research applications.OVA 257-264 (SIINFEKL) is a well-characterized, immunodominant epitope derived from chicken ovalbumin protein (Uniprot P01012). Its ability to reliably stimulate T cells, especially CD8+ T cells, allows researchers to:
* Quantify Peptide Epitope Specificity: By using this peptide, scientists can precisely measure the specificity of T-cell receptors and determine how strongly T cells recognize the SIINFEKL epitope.
* Detect Immune Responses: Techniques such as ELISPOT assays are employed to quantify effector cells releasing cytokines like Interferon-gamma (IFN-γ) upon stimulation with the OVA (257-264) peptide, indicating a robust T-cell response.
* Study T-Cell Activation: The peptide serves as a standard reagent to induce T-cell activation in vitro, facilitating studies on immune cell function, signaling pathways, and the development of immune tolerance or memory.
* Develop Vaccines and Therapies: Understanding how the OVA peptide is presented and recognized by the immune system can inform the design of therapeutic vaccines aimed at enhancing anti-tumor immunity or modulating immune responses in autoimmune diseases.OVA Peptide（257-264）是OVA的I 类(Kb)-限制性肽表位，由Class I MHC分子H-2Kb ...OVA（257–264）表位的来源是CrlOVA（257-264）（CrlOVA）融合蛋白、麦芽糖 ...
Furthermore, the OVA peptide (257-264) is also used in conjunction with antibodies, such as the eBio25-D1.16 antibody, for flow cytometric analysis and immunohistochemical staining, aiding in the identification and characterization of specific immune cell populations.
While the SIINFEKL sequence is the most common form, researchers may encounter variations or related peptides used for comparative studies or to investigate immune escape mechanisms. For instance, modified versions like the OVA 257-264 scrambled peptide (FILKSINE) are synthesized to understand the importance of specific amino acid positions within the epitope for T-cell recognition. Another related peptide often studied is OVA peptide (323-339), which is presented by MHC Class II molecules and elicits a different type of T-cell response, primarily from CD4+ T helper cellsOvalbumin (257-264) chicken 97 (HPLC) pOV8. The trifluoroacetate (TFA) salt form of the OVA peptide (257-264) is also common, often used to improve solubility and stability for experimental usePeptide Institute, Inc. is a global supplier ofOVA Peptide (257-264) from Japan. Name:OVA Peptide (257-264), Code:4529-v, T-cell Activating Peptide..
In summary, the OVA peptide (257-264) is more than just a sequence of amino acids; it is a powerful immunological probe. Its defined structure, origin from ovalbumin, and specific presentation by H-2Kb MHC Class I molecules make it indispensable for advancing our understanding of cell-mediated immunity and for developing novel immunotherapies.
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