p113 peptide Peptide - P113+ 抗菌 胜 肽 P-113 peptides P113 Peptide: A Powerful Antimicrobial Agent for Oral Health

P113漱 口水 The p113 peptide, a potent antimicrobial peptide (AMP) derived from human salivary histatin 5, is emerging as a significant player in advanced oral care. This naturally occurring peptide possesses broad-spectrum antibacterial and antifungal properties, making it highly effective against a range of oral pathogens, including *Streptococcus mutans*, a primary culprit in dental caries and periodontal disease. The p113 peptide's ability to selectively inhibit harmful bacteria while maintaining a healthy oral microbiome underscores its potential for revolutionizing how we approach dental hygiene and disease preventionWith broad-spectrum antibacterial and antifungal properties,P113selectively inhibits Streptococcus mutans and other oral pathogens, maintaining a healthy oral ....

Understanding the P113 Peptide

P113 is a short peptide composed of 12 amino acids, with the sequence AKRHHGYKRKFH. Its origin from histatin 5, a protein found in human saliva, highlights its inherent biocompatibilityEfficacy of antimicrobial peptide P113 oral health care .... Research indicates that p113 retains the crucial antibacterial and antifungal activities of its parent protein. Its mechanism of action often involves disrupting microbial cell membranes, leading to cell death.作者：YF Wu·2024·被引用次数：4—指紋 · Health Care Medicine and Dentistry 100% · Clinical Assessment Medicine and Dentistry 100% · Tooth Plaque Medicine and Dentistry 100%. Saralasin Medicine ... Unlike harsh chemical antiseptics, p113 demonstrates selectivity, targeting pathogenic microorganisms with minimal impact on beneficial oral floraTargeted antimicrobial self-assembly peptide hydrogel with .... This selectivity is a key advantage for applications in oral health, where preserving the natural balance of the microbiome is essential.2026年1月7日—In addition, decreased dental plaque weight, dental plaque index, and gingival index were all observed in the experimental group. Conclusion The ...

Applications in Oral Health

The most prominent application of the p113 peptide is in oral health care products.Targeted antimicrobial self-assembly peptide hydrogel with ... Studies have demonstrated its efficacy in reducing oral bacteria numbers and inhibiting dental plaque formation.High Level Expression and Purification of the Clinically ... This translates to potential benefits in preventing and managing conditions such as:

* Dental Caries: By targeting *Streptococcus mutans*, p113 can help reduce the bacterial load responsible for acid production that erodes tooth enamel.P-113 | Antimicrobial Peptide

* Periodontal Disease: P113 has shown promise in combating bacteria associated with gum inflammation and bone loss, such as *Porphyromonas gingivalis*P-113is an antimicrobialpeptide(AMP) derived from the human salivary protein histatin 5.P-113is active against clinically important microorganisms such ....

* Bad Breath (Halitosis): Its antimicrobial action can help control the volatile sulfur compounds produced by certain oral bacteria, contributing to fresher breath.

Products like p113+ mouthwash and oral sprays are being developed and utilized, leveraging the peptide's power to offer a fluoride-free alternative for comprehensive oral hygiene2025年6月1日—P-113-DPS inhibited the growth and cell viability of S. mutans. Treatment withP-113-DPS resulted in decreased acidogenicity and aciduricity, .... The peptide's ability to work synergistically within these formulations enhances their overall effectiveness.

Research and Development of P113

The scientific community has shown considerable interest in the p113 peptide, leading to extensive research and development.作者：H Wang·2018·被引用次数：55—Therefore, Nal-P-113effectively reduces periodontal pathogens and ameliorates periodontal status. 1. Introduction. Periodontal disease consists ... Several modified versions of p113 have been explored to enhance its properties, such as Nal-P-113, which features a substitution for improved salt resistance. Clinical trials, including Phase II trials recognized by the FDA, have been conducted for p113-based products, suggesting a pathway towards wider clinical adoptionAntimicrobial Peptide P-113-DPS Suppresses the Cariogenic .... The peptide's safety profile is also a significant consideration, with studies indicating low toxicity and minimal irritation to oral tissues.Targeted antimicrobial self-assembly peptide hydrogel with ... Patents have been secured in multiple regions for p113 and its applications, reflecting its commercial and therapeutic potential.

Future Prospects

The p113 peptide represents a significant advancement in antimicrobial therapeutics, particularly for oral healthEfficacy of antimicrobial peptide P113 oral health care .... Its natural origin, potent efficacy against a broad spectrum of pathogens, and selective action make it a highly promising agent. As research continues and clinical applications expand, p113 is poised to become a cornerstone in the development of next-generation oral care products, offering effective protection against common dental issues and contributing to overall oral well-being. The ongoing exploration into its interaction mechanisms and the development of novel delivery systems will further solidify its role in both preventive and therapeutic oral health strategies.P113+獨家專利活性肽能對抗壞菌，以滿足益菌的生長條件，來維持微生物菌叢平衡。運用於口腔保健，從牙齒、牙齦、口腔內部，全方位保護，去壞留好；更可進階運用在肌膚及人體各處 ...