Siinfekl molecular Weight The ova257-264 peptide, also known as SIINFEKL, is a well-characterized octameric peptide derived from ovalbumin.2022年4月6日—10mg， 25mg，100mg，500mg, 1g 包装 南京肽业出品，需要咨询或者订购，请联系： QQ: 2875621389，15358616852, [email protected] This peptide is recognized as a class I (Kb)-restricted peptide epitope and is crucial in immunological research for its role in presenting antigens to T cells. Specifically, it is presented by the H-2Kb MHC class I molecule, making it a key component in studies involving cellular immunity and the activation of CD8+ cytotoxic T-cell responsesAB_925775. Its significance is further highlighted by its use in stimulating T cells in PBMCs and quantifying peptide epitope specificity.OVA peptide - MedchemExpress.com
The ova257-264 peptide represents a specific sequence (amino acids 257-264) from the ovalbumin protein, which is the primary protein found in egg whiteName.OVA257-264 (SIINFEKL) peptide bound to H-2Kb Monoclonal Antibody(eBio25-D1.16 (25-D1.16)), PE, eBioscience. ID. AB_925775. Catalog number. 12-5743-81 .... Ovalbumin itself is a highly immunogenic protein, and this particular peptide fragment has been identified as an immunodominant epitopeOVA Peptide (257-264). Its structure and function are intimately linked to its presentation by the H-2Kb molecule, a specific type of MHC class I protein found in certain mouse strains. This interaction is fundamental for initiating an adaptive immune response, particularly involving T cells. Researchers commonly utilize this peptide in various experimental setups to probe immune system function, develop vaccines, or study autoimmune diseases and allergies.This is aclass I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC m
The ova257-264 peptide serves as a vital tool in immunological research, primarily for its ability to elicit a specific T-cell mediated immune response.OVA peptide (257-264) TFA salt | 138831-86-4 | PP47154 Its well-defined nature as a class I (Kb)-restricted peptide epitope allows for precise investigations into T-cell activation and function.
* T-cell Stimulation and Assay Development: The peptide is frequently used to stimulate T cells in peripheral blood mononuclear cells (PBMCs).OVA peptide (257-264) TFA salt | 138831-86-4 | PP47154 This stimulation is a critical step in various assays designed to measure immune responses, such as the ELISPOT assay, which quantifies the release of specific cytokines like interferon-gamma (IFN-γ). By using the ova257-264 peptide, researchers can accurately assess peptide epitope specificity and the frequency of effector cells.
* CD8+ Cytolytic T-cell Response Detection: Studies have demonstrated that ova257-264 peptides are effective in detecting a strong CD8+ cytolytic T-cell response. This makes it invaluable for understanding cellular immunity, where CD8+ T cells play a pivotal role in eliminating infected or cancerous cellsOVA (257-264), scrambled | Bioactive Peptide.
* Monoclonal Antibody Development and Validation: The ova257-264 peptide, particularly when bound to H-2Kb, is recognized by specific monoclonal antibodies, such as the 25-D1.16 antibody.OVA 257-264 scrambled (FILKSINE) These antibodies are essential reagents for identifying and quantifying cells presenting this specific peptide-MHC complex, further aiding in the study of antigen presentation and T-cell interactions.
* Research-Grade Applications: For laboratory use, research-grade ova257-264 peptide is available from various suppliers. These preparations are typically of high purity and are used in metabolic research studies and other experimental applications where precise immunological reagents are requiredOVA Peptide(257-264) TFA | OVA表位肽.
While ova257-264 is a prominent epitope, understanding its context within the broader family of ovalbumin-derived peptides is also importantOVA 257-264is used to stimulate T cells in PBMCsand to quantify peptide epitope specificity and IFN-γ releasing effector cells by ELISPOT assay. OVA 257-264 ....
* OVA 323-339: This is another well-known peptide from ovalbumin, distinct from ova257-264. Unlike ova257-264, which is recognized by CD8+ T cells, ova323-339 is typically presented by MHC class II molecules and is associated with CD4+ T-cell responses, often related to allergic reactions.
* Scrambled Peptides: To serve as controls in experiments, scrambled versions of peptides like ova257-264 are synthesized. For instance, a scrambled ova257-264 peptide (e.g., FILKSINE) is used to ensure that observed immune responses are specific to the original peptide sequence and not due to non-specific interactionsOVA Peptide (257-264). These scrambled peptides are considered biologically inactive in terms of specific T-cell recognition.
When acquiring and using the ova257-264 peptide, several factors are important for researchersOVA(257-264) | 138831-86-4 | SIINFEKL.
* Purity and Formulation: The peptide is often supplied in a lyophilized form, typically as a trifluoroacetate (TFA) salt, requiring reconstitution before use. High purity, often greater than 95% or 97% by HPLC, is critical for reliable experimental results.
* Quantity and Packaging: The peptide is available in various quantities, from milligrams to grams, to suit different research needs. Packaging and shipping conditions are also important to maintain peptide stability.OVA (257-264), scrambled | Bioactive Peptide
* Supplier Reputation: Given the critical nature of immunological research, sourcing from reputable suppliers that provide detailed product specifications, certificates of analysis, and relevant citations is highly recommended.
In summary, the ova257-264 peptide is a fundamental tool in immunology, enabling detailed study of T-cell mediated immunity through its specific interaction with H-2Kb MHC class I moleculesBuy Ova 257 264 Peptide for Sale Online. Its applications span from basic research on T-cell activation to the development of diagnostic and therapeutic strategiesIt has been demonstrated thatOVA 257-264 peptides can be used to detect a strong CD8+ cytolytic T-cell response[2]. OVA 323-339 encompasses an allergenic and ....
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