LL-37peptidebenefits The antimicrobial peptide LL-37 stands as a crucial element of the human innate immune system, playing a multifaceted role in defending against a wide array of pathogens.LL-37 isa human antimicrobial peptideof the cathelicidin family and corresponds to the 134-170 segment of human cationic antimicrobial protein 18 (hCAP18). As the sole human member of the cathelicidin family, this 37-amino acid peptide, also known as hCAP18, has garnered significant attention for its potent antimicrobial and immunomodulatory functions. LL-37 effectively combats bacteria, fungi, and viruses, demonstrating particular promise against antibiotic-resistant strains, and is increasingly considered a potential alternative to conventional antibiotics.
LL-37 is synthesized as part of the larger precursor protein hCAP18 and is released as an active peptide in response to infection or inflammation. Its presence is vital in the first line of defense against local infections, found throughout the body, including on the skin and mucosal surfacesLL-37 functions as an immune modulatorinducing expression of inflammatory genes including adhesion molecules and chemokines in human endothelial cells. C .... This peptide serves a critical role in the innate immune system, defending against bacterial infections by directly killing microbes and by modulating the host's immune response.
The primary function of LL-37 is its broad-spectrum antimicrobial activity.作者：Y Engelberg·2020·被引用次数：158—Here, we demonstrate theself-assembly of the antimicrobial human LL-37 active core(residues 17–29) into a protein fibril of densely packed ... It effectively targets a wide range of pathogens, including Gram-positive and Gram-negative bacteria, fungi, and viruses. LL-37's mechanism of action typically involves binding to microbial cell membranes, disrupting their integrity, and leading to cell death. Its amphipathic alpha-helical structure is key to this process, allowing it to interact with and permeabilize lipid bilayers characteristic of microbial membranesStructure and organization of the human antimicrobial .... This direct killing capacity makes LL-37 a potent weapon against even multi-drug resistant bacterial strains.作者：A Pavelka·2024·被引用次数：12—LL-37 peptide has potent antimicrobial effectsagainst current multi-drug resistant bacterial strains. The peptide itself is also characterized ...
Beyond its direct antimicrobial effects, LL-37 is a potent immune modulator. It can influence various immune cells, including neutrophils and epithelial cells, and plays a significant role in regulating inflammation. LL-37 can induce the expression of inflammatory genes, such as chemokines and adhesion molecules, contributing to the recruitment of immune cells to the site of infection. It also has the capacity to suppress excessive inflammation, helping to prevent tissue damage caused by an overactive immune response. This dual action of direct pathogen elimination and immune system regulation highlights LL-37's comprehensive role in host defense作者：GT Qin·2015·被引用次数：25—Antimicrobial peptides (AMPs) are part of the immune system in a wide range of organisms.They generally carry positive chargesunder physiological ....
The unique properties of LL-37 have positioned it as a promising candidate for various therapeutic applications, particularly in the face of rising antibiotic resistanceLL-37, the neutrophil granule- and epithelial cell-derived cathelicidin .... Its ability to combat a broad spectrum of microbes, including those resistant to conventional treatments, makes it an attractive alternative2008年9月23日—As a key component of the innate immunity system,human cathelicidin LL-37plays an essential role in protecting humans against infectious .... Research is exploring its use in treating localized infections, wound healing, and inflammatory conditions.
The increasing prevalence of multidrug-resistant bacteria poses a significant global health threatAntimicrobial peptide LL-37 on surfaces presenting .... LL-37 offers a potential solution due to its distinct mechanisms of action, which are less prone to inducing resistance compared to traditional antibiotics. Its ability to disrupt bacterial membranes and modulate host immunity presents a different approach to infection control.作者：KE Ridyard·2021·被引用次数：268—The human antimicrobial peptide LL-37has been considered as a potential alternative to conventional antibioticsas it displays broad spectrum antibacterial ... Furthermore, LL-37 has demonstrated both antimicrobial and antibiofilm activities, which are crucial for tackling persistent infections often associated with resistant bacteria.
LL-37 has also been implicated in promoting wound healing and tissue repair. Its immunomodulatory effects can help to create an environment conducive to healing by managing inflammation and recruiting cells involved in tissue regeneration. Studies suggest that LL-37 and its fragments can accelerate the healing process, making it a potential agent for topical applications in wound care.LL-37 - an overview | ScienceDirect Topics
The antimicrobial peptide LL-37 is a vital component of the human immune system, offering both direct antimicrobial action and sophisticated immune modulation.Recombinant production of human antimicrobial peptide LL Its broad-spectrum efficacy against a range of pathogens, including antibiotic-resistant strains, coupled with its role in inflammation control and tissue repair, underscores its therapeutic potential.作者：GT Qin·2015·被引用次数：25—Antimicrobial peptides (AMPs) are part of the immune system in a wide range of organisms.They generally carry positive chargesunder physiological ... As research continues to unravel the full scope of LL-37's functions, it holds significant promise as a novel therapeutic agent in combating infectious diseases and supporting host defense mechanisms.作者：E Sancho-Vaello·2020·被引用次数：133—The human cathelicidin LL-37serves a critical role in the innate immune system defending bacterial infections. LL-37 can interact with ...
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